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Target
Perforin-1
Ligand
BDBM50275016
Substrate
n/a
Meas. Tech.
ChEMBL_495622 (CHEMBL1000314)
IC50
>20000±n/a nM
Citation
 Lena, G; Trapani, JA; Sutton, VR; Ciccone, A; Browne, KA; Smyth, MJ; Denny, WA; Spicer, JA Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin. J Med Chem 51:7614-24 (2009) [PubMed]  Article 
Target
Name:
Perforin-1
Synonyms:
PERF_HUMAN | PFP | PRF1
Type:
PROTEIN
Mol. Mass.:
61392.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1285138
Residue:
555
Sequence:
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW
  
Inhibitor
Name:
BDBM50275016
Synonyms:
(Z)-1-((6-(Benzyloxy)-5-methoxy-1H-indol-2-yl)methylene)-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one | CHEMBL458834
Type:
Small organic molecule
Emp. Form.:
C25H20N2O4S
Mol. Mass.:
444.502
SMILES:
COc1cc2cc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)[nH]c2cc1OCc1ccccc1
Structure:
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