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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50254533
Substrate
n/a
Meas. Tech.
ChEMBL_558765 (CHEMBL1019894)
IC50
2010.0±n/a nM
Citation
 Porter, J; Payne, A; de Candole, B; Ford, D; Hutchinson, B; Trevitt, G; Turner, J; Edwards, C; Watkins, C; Whitcombe, I; Davis, J; Stubberfield, C Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors. Bioorg Med Chem Lett 19:230-3 (2008) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50254533
Synonyms:
CHEMBL513318 | N,N-dibutyl-5-methyl-1-(2-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)-1H-pyrazole-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C29H36N4O2
Mol. Mass.:
472.6217
SMILES:
CCCCN(CCCC)C(=O)c1cc(C)n(n1)-c1ccccc1C(=O)N1CCc2ccccc2C1
Structure:
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