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Target
Adenosine receptor A2a
Ligand
BDBM50254399
Substrate
n/a
Meas. Tech.
ChEMBL_560532 (CHEMBL1021382)
Ki
8.6±n/a nM
Citation
 Gillespie, RJ; Bamford, SJ; Botting, R; Comer, M; Denny, S; Gaur, S; Griffin, M; Jordan, AM; Knight, AR; Lerpiniere, J; Leonardi, S; Lightowler, S; McAteer, S; Merrett, A; Misra, A; Padfield, A; Reece, M; Saadi, M; Selwood, DL; Stratton, GC; Surry, D; Todd, R; Tong, X; Ruston, V; Upton, R; Weiss, SM Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines. J Med Chem 52:33-47 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50254399
Synonyms:
7-(2-Furyl)-3-(5-indazolylmethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine | CHEMBL512812
Type:
Small organic molecule
Emp. Form.:
C16H12N8O
Mol. Mass.:
332.3195
SMILES:
Nc1nc(-c2ccco2)c2nnn(Cc3ccc4[nH]ncc4c3)c2n1
Structure:
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