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Target
Potassium voltage-gated channel subfamily KQT member 1
Ligand
BDBM50117913
Substrate
n/a
Meas. Tech.
ChEMBL_545265 (CHEMBL1020711)
IC50
240±n/a nM
Citation
 Du, L; Li, M; Yang, Q; Tang, Y; You, Q; Xia, L Molecular hybridization, synthesis, and biological evaluation of novel chroman I(Kr) and I(Ks) dual blockers. Bioorg Med Chem Lett 19:1477-80 (2009) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 1
Synonyms:
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 | KCNQ1 | KCNQ1_CAVPO | KQT-like 1 | KVLQT1 | Potassium voltage-gated channel subfamily KQT member 1 | Voltage-gated potassium channel subunit Kv7.1
Type:
PROTEIN
Mol. Mass.:
74450.11
Organism:
Cavia porcellus
Description:
ChEMBL_88894
Residue:
671
Sequence:
MAAASSPPRTERKRGGWGRLLGSRRGSASLAKKCPFSLELAEGGPAGGTLYAPVAPPGALSPGSPAPPASPAAPPAGLELGPRPPVSLDPRVSIYSARRPLLARTHIQGRVYNFLERPTGWKCFVYHFAVFLIVLACLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYVRKPARSHTLLSPSPKPKKSAMVRKKKFKPDKDNGVSPGEKMLTVPHITCDPPEERRPDHFSVDGYDSSVRKSPTLLEVSPTHFMRTNSFAEDLDLEGETLLTPITHVSQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFIPISEKSKDRGSNTIGARLNRVEDKVTQLDQRLVVITDMLHQLLSLHQGGPHSGGGPQMVQPCSEDGSIHPELFLPSNSLPTYEQLTVPQRGPDEAS
  
Inhibitor
Name:
BDBM50117913
Synonyms:
(E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamino)-3-(4-(4-methylpiperazin-1-yl)butyl)imidazolidine-2,4-dione | 1-{[1-[5-(4-Chloro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amino}-3-[4-(4-methyl-piperazin-1-yl)-butyl]-imidazolidine-2,4-dione | 1-{[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-amino}-3-[4-(4-methyl-piperazin-1-yl)-butyl]-imidazolidine-2,4-dione(Azimilide) | AZIMILIDE | AZIMILIDE DIHYDROCHLORIDE | CHEMBL123558
Type:
Small organic molecule
Emp. Form.:
C23H28ClN5O3
Mol. Mass.:
457.953
SMILES:
CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1 |w:14.13|
Structure:
Search PDB for entries with ligand similarity: