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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50125099
Substrate
n/a
Meas. Tech.
ChEMBL_566709 (CHEMBL961701)
Ki
0.47±n/a nM
Citation
 Holl, R; Schepmann, D; Fröhlich, R; Grünert, R; Bednarski, PJ; Wünsch, B Dancing of the second aromatic residue around the 6,8-diazabicyclo[3.2.2]nonane framework: influence on sigma receptor affinity and cytotoxicity. J Med Chem 52:2126-37 (2009) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50125099
Synonyms:
1-Benzyl-4-(4-methoxy-benzyl)-piperazine | 1-benzyl-4-(4-methoxybenzyl)piperazine | CHEMBL163876
Type:
Small organic molecule
Emp. Form.:
C19H24N2O
Mol. Mass.:
296.4067
SMILES:
COc1ccc(CN2CCN(Cc3ccccc3)CC2)cc1
Structure:
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