Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50259391
Substrate
n/a
Meas. Tech.
ChEMBL_500189 (CHEMBL980656)
IC50
19000±n/a nM
Citation
 Debenham, JS; Madsen-Duggan, CB; Wang, J; Tong, X; Lao, J; Fong, TM; Schaeffer, MT; Xiao, JC; Huang, CC; Shen, CP; Sloan Stribling, D; Shearman, LP; Strack, AM; Euan Macintyre, D; Hale, JJ; Walsh, TF Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation. Bioorg Med Chem Lett 19:2591-4 (2009) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50259391
Synonyms:
4-(5-tert-butyl-9-(4-chlorophenyl)-3-oxo-2,3-dihydropyrido[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-8-yl)-3-chlorobenzonitrile | CHEMBL467329
Type:
Small organic molecule
Emp. Form.:
C25H18Cl2N6O
Mol. Mass.:
489.356
SMILES:
CC(C)(C)c1nc2nc(-c3ccc(cc3Cl)C#N)c(cc2c2n[nH]c(=O)n12)-c1ccc(Cl)cc1
Structure:
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