Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50280993
Substrate
n/a
Meas. Tech.
ChEBML_201267
IC50
16±n/a nM
Citation
 Reddy, NL; Fischer, JB; Burke-Howie, KJ; Barmettler, P; Rhodes, MR; Weber, E; Keana, JF N,N′-disubstituted acetamidines as high affinity sigma receptor ligands Bioorg Med Chem Lett 3:2113-2116 (1993)    Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50280993
Synonyms:
CHEMBL67388 | N,N'-Di-adamantan-1-yl-acetamidine
Type:
Small organic molecule
Emp. Form.:
C22H34N2
Mol. Mass.:
326.5188
SMILES:
CC(NC12CC3CC(CC(C3)C1)C2)=NC12CC3CC(CC(C3)C1)C2 |w:13.16,TLB:17:18:22:16.15.21,10:9:12:5.4.6,10:5:12:9.11.8,23:14:21:18.17.19,THB:17:16:22:18.23.19,8:9:4:7.12.6,8:7:4:9.11.10,23:18:14.22.15:21,TEB:13:14:21:18.17.19,13:14:16.17.21:19|
Structure:
Search PDB for entries with ligand similarity: