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Target
Neutrophil elastase
Ligand
BDBM50281012
Substrate
n/a
Meas. Tech.
ChEMBL_63652 (CHEMBL675539)
IC50
>20000±n/a nM
Citation
 Finke, PE; Dahlgren, ME; Weston, H; Maycock, AL; Doherty, JB Inhibition of human leukocyte elastase. 5. Inhibition by 6-alkyl substituted penem benzyl esters. Bioorg Med Chem Lett 3:2277-2282 (1993)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50281012
Synonyms:
(R)-7-Oxo-3-phenyl-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzyl ester | CHEMBL76180
Type:
Small organic molecule
Emp. Form.:
C19H15NO3S
Mol. Mass.:
337.392
SMILES:
O=C(OCc1ccccc1)C1=C(S[C@@H]2CC(=O)N12)c1ccccc1 |t:11|
Structure:
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