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Target
Neutrophil elastase
Ligand
BDBM50281019
Substrate
n/a
Meas. Tech.
ChEBML_63974
IC50
1000±n/a nM
Citation
 Finke, PE; Dahlgren, ME; Weston, H; Maycock, AL; Doherty, JB Inhibition of human leukocyte elastase. 5. Inhibition by 6-alkyl substituted penem benzyl esters. Bioorg Med Chem Lett 3:2277-2282 (1993)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50281019
Synonyms:
(R)-6-Isopropyl-7-oxo-3-phenyl-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzyl ester | CHEMBL74344
Type:
Small organic molecule
Emp. Form.:
C22H21NO3S
Mol. Mass.:
379.472
SMILES:
CC(C)C1[C@H]2SC(=C(N2C1=O)C(=O)OCc1ccccc1)c1ccccc1 |c:6|
Structure:
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