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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50281493
Substrate
n/a
Meas. Tech.
ChEBML_28337
IC50
168±n/a nM
Citation
 Trivedi, BK; Stoeber, TL; Stanfield, RL; Essenburg, AD; Hamelehle, KL; Krause, BR Substituted N,N′-diphenyl ureas as potent inhibitors of acyl-CoA:Cholesterol acyltransferase (ACAT) Bioorg Med Chem Lett 3:259-262 (1993)    Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50281493
Synonyms:
1-(4-tert-Butyl-phenyl)-3-(2,6-diisopropyl-phenyl)-urea | CHEMBL89574
Type:
Small organic molecule
Emp. Form.:
C23H32N2O
Mol. Mass.:
352.513
SMILES:
CC(C)c1cccc(C(C)C)c1NC(=O)Nc1ccc(cc1)C(C)(C)C
Structure:
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