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Target
Substance-K receptor
Ligand
BDBM50281774
Substrate
n/a
Meas. Tech.
ChEBML_142867
Ki
>100±n/a nM
Citation
 Emonds-Alt, X; Proietto, V; Broeck, DV; Vilain, P; Advenier, C; Neliat, G; Fur, GL; Brelère, JC Pharmacological profile and chemical synthesis of SR 48968, a non-peptide antagonist of the neurokinin A (NK2) receptor Bioorg Med Chem Lett 3:925-930 (1993)    Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R_RAT | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | SKR | Substance-K receptor | Tac2r | Tachykinin receptor 2 | Tacr2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43868.63
Organism:
Rattus norvegicus (Rat)
Description:
Neurokinin NK2 TACR2 Murine::P16610
Residue:
390
Sequence:
MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMTGDMTHSEATNGQVGSPQDGEPAGPICKAQA
  
Inhibitor
Name:
BDBM50281774
Synonyms:
CHEMBL366382 | N-[4-(4-Acetylamino-4-phenyl-piperidin-1-yl)-2-(3,4-dichloro-phenyl)-butyl]-benzamide
Type:
Small organic molecule
Emp. Form.:
C30H33Cl2N3O2
Mol. Mass.:
538.508
SMILES:
CC(=O)NC1(CCN(CCC(CNC(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1)c1ccccc1
Structure:
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