Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50288434
Substrate
n/a
Meas. Tech.
ChEBML_157739
Ki
0.190000±n/a nM
Citation
 Rodgers, JD; Johnson, BL; Wang, H; Greenberg, RA; Erickson-Viitanen, S; Klabe, RM; Cordova, BC; Rayner, MM; Lam, GN; Chang, CH Potent cyclic urea HIV protease inhibitors with benzofused heterocycles as P2/P2′ groups Bioorg Med Chem Lett 6:2919-2924 (1996)    Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50288434
Synonyms:
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis-(2,2-dioxo-2,3-dihydro-1H-2lambda*6*-benzo[1,2,5]thiadiazol-5-ylmethyl)-5,6-dihydroxy-[1,3]diazepan-2-one | CHEMBL316939
Type:
Small organic molecule
Emp. Form.:
C33H34N6O7S2
Mol. Mass.:
690.789
SMILES:
O[C@@H]1[C@@H](O)[C@@H](Cc2ccccc2)N(Cc2ccc3NS(=O)(=O)Nc3c2)C(=O)N(Cc2ccc3NS(=O)(=O)Nc3c2)[C@@H]1Cc1ccccc1
Structure:
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