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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50289329
Substrate
n/a
Meas. Tech.
ChEBML_158936
IC50
9000±n/a nM
Citation
 Roy, P; Leblanc, Y; Ball, RG; Brideau, C; Chan, CC; Chauret, N; Cromlish, W; Ethier, D; Gauthier, JY; Gordon, R; Greig, G; Guay, J; Kargman, S; Lau, CK; O'Neill, G; Silva, J; Thérien, M; Staden, Cv; Wong, E; Xu, L A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles Bioorg Med Chem Lett 7:57-62 (1997)    Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Enzyme
Mol. Mass.:
68692.62
Organism:
Homo sapiens (Human)
Description:
P23219
Residue:
599
Sequence:
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
  
Inhibitor
Name:
BDBM50289329
Synonyms:
6-(4-Methanesulfonyl-phenyl)-5-phenyl-2-trifluoromethyl-thiazolo[3,2-b][1,2,4]triazole | CHEMBL157358
Type:
Small organic molecule
Emp. Form.:
C18H12F3N3O2S2
Mol. Mass.:
423.432
SMILES:
CS(=O)(=O)c1ccc(cc1)-c1c(sc2nc(nn12)C(F)(F)F)-c1ccccc1
Structure:
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