Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2
Ligand
BDBM50293179
Substrate
n/a
Meas. Tech.
ChEMBL_496946 (CHEMBL1002041)
IC50
9±n/a nM
Citation
 Choong, IC; Serafimova, I; Fan, J; Stockett, D; Chan, E; Cheeti, S; Lu, Y; Fahr, B; Pham, P; Arkin, MR; Walker, DH; Hoch, U A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties. Bioorg Med Chem Lett 18:5763-5 (2009) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50293179
Synonyms:
5-((5-tert-butyloxazol-2-yl)methylthio)-N-cyclohexylthiazol-2-amine | CHEMBL496785
Type:
Small organic molecule
Emp. Form.:
C17H25N3OS2
Mol. Mass.:
351.53
SMILES:
CC(C)(C)c1cnc(CSc2cnc(NC3CCCCC3)s2)o1
Structure:
Search PDB for entries with ligand similarity: