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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50299116
Substrate
n/a
Meas. Tech.
ChEMBL_591830 (CHEMBL1042379)
EC50
1360±n/a nM
Citation
 Fracchiolla, G; Laghezza, A; Piemontese, L; Tortorella, P; Mazza, F; Montanari, R; Pochetti, G; Lavecchia, A; Novellino, E; Pierno, S; Conte Camerino, D; Loiodice, F New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function. J Med Chem 52:6382-93 (2009) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50299116
Synonyms:
CHEMBL574606 | rac-2-(4-Phenylethynyl-phenoxy)-3-phenyl-propanoic Acid
Type:
Small organic molecule
Emp. Form.:
C23H18O3
Mol. Mass.:
342.3872
SMILES:
OC(=O)C(Cc1ccccc1)Oc1ccc(cc1)C#Cc1ccccc1
Structure:
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