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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50300838
Substrate
n/a
Meas. Tech.
ChEMBL_598948 (CHEMBL1049084)
IC50
511±n/a nM
Citation
 Bernotas, RC; Lenicek, S; Antane, S; Cole, DC; Harrison, BL; Robichaud, AJ; Zhang, GM; Smith, D; Platt, B; Lin, Q; Li, P; Coupet, J; Rosenzweig-Lipson, S; Beyer, CE; Schechter, LE Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. Bioorg Med Chem 17:5153-63 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50300838
Synonyms:
CHEMBL565552 | N,N-Dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1Hpyrrolo[2,3-b]pyridin-1-yl]ethyl}amine
Type:
Small organic molecule
Emp. Form.:
C21H21N3O2S
Mol. Mass.:
379.475
SMILES:
CN(C)CCn1cc(c2cccnc12)S(=O)(=O)c1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: