Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 3
Ligand
BDBM50300899
Substrate
n/a
Meas. Tech.
ChEMBL_600877 (CHEMBL1042835)
IC50
0.9±n/a nM
Citation
Du, X; Gustin, DJ; Chen, X; Duquette, J; McGee, LR; Wang, Z; Ebsworth, K; Henne, K; Lemon, B; Ma, J; Miao, S; Sabalan, E; Sullivan, TJ; Tonn, G; Collins, TL; Medina, JC Imidazo-pyrazine derivatives as potent CXCR3 antagonists. Bioorg Med Chem Lett 19:5200-4 (2009) [PubMed] Article
More Info.:
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40665.65
Organism:
Human
Description:
n/a
Residue:
368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
Inhibitor
Name:
BDBM50300899
Synonyms:
(R)-N-(1-(3-(4-cyanophenyl)-8-cyclopropylimidazo[1,2-a]pyrazin-2-yl)ethyl)-N-(2-(ethylsulfonyl)ethyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamide | CHEMBL570665
Type:
Small organic molecule
Emp. Form.:
C31H29F4N5O3S
Mol. Mass.:
627.652
SMILES:
CCS(=O)(=O)CCN([C@H](C)c1nc2c(nccn2c1-c1ccc(cc1)C#N)C1CC1)C(=O)Cc1ccc(c(F)c1)C(F)(F)F |r|