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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50304902
Substrate
n/a
Meas. Tech.
ChEMBL_606325 (CHEMBL1070647)
IC50
3.2±n/a nM
Citation
 Stock, N; Baccei, C; Bain, G; Broadhead, A; Chapman, C; Darlington, J; King, C; Lee, C; Li, Y; Lorrain, DS; Prodanovich, P; Rong, H; Santini, A; Zunic, J; Evans, JF; Hutchinson, JH; Prasit, P 5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor. Bioorg Med Chem Lett 20:213-7 (2010) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Human
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50304902
Synonyms:
(S)-3-(5-((1-acetylindolin-2-yl)methoxy)-3-(tert-butylthio)-1-(4-(6-methoxy-1,2-dihydropyridazin-3-yl)benzyl)-1H-indol-2-yl)-2,2-dimethylpropanoic acid | CHEMBL594773
Type:
Small organic molecule
Emp. Form.:
C40H46N4O5S
Mol. Mass.:
694.882
SMILES:
COC1=NN=C(CC1)c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OC[C@@H]4Cc5ccccc5N4C(C)=O)ccc23)cc1 |r,c:4,t:2|
Structure:
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