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Target
Histamine H1 receptor
Ligand
BDBM50311327
Substrate
n/a
Meas. Tech.
ChEMBL_621600 (CHEMBL1113032)
Ki
199±n/a nM
Citation
 Martin, RE; Mohr, P; Maerki, HP; Guba, W; Kuratli, C; Gavelle, O; Binggeli, A; Bendels, S; Alvarez-Sánchez, R; Alker, A; Polonchuk, L; Christ, AD Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists. Bioorg Med Chem Lett 19:6106-13 (2009) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50311327
Synonyms:
CHEMBL1077908 | N-(2-(1-(3-ethoxy-4-methoxybenzyl)piperidin-4-ylamino)benzo[d]oxazol-5-yl)benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C28H32N4O5S
Mol. Mass.:
536.642
SMILES:
CCOc1cc(CN2CCC(CC2)Nc2nc3cc(NS(=O)(=O)c4ccccc4)ccc3o2)ccc1OC
Structure:
Search PDB for entries with ligand similarity: