Reaction Details
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Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50318259
Substrate
n/a
Meas. Tech.
ChEMBL_629295 (CHEMBL1103975)
IC50
46000±n/a nM
Citation
Ii, K; Ichikawa, S; Al-Dabbagh, B; Bouhss, A; Matsuda, A Function-oriented synthesis of simplified caprazamycins: discovery of oxazolidine-containing uridine derivatives as antibacterial agents against drug-resistant bacteria. J Med Chem 53:3793-813 (2010) [PubMed] Article More Info.:
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_BACSU | mraY
Type:
PROTEIN
Mol. Mass.:
35531.14
Organism:
Bacillus subtilis
Description:
ChEMBL_796247
Residue:
324
Sequence:
MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKSHQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIKVVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVLFMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFLVFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFKTTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL
Inhibitor
Name:
BDBM50318259
Synonyms:
6-Amino-5-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-6-deoxy-1-N-(4-octylphenyl)(uracil-1-yl)-beta-D-glycero-L-talo-heptofuranuronamide Trifluoroacetic Salt | CHEMBL1095315
Type:
Small organic molecule
Emp. Form.:
C30H45N5O10
Mol. Mass.:
635.7058
SMILES:
CCCCCCCCc1ccc(NC(=O)[C@@H](N)[C@H](O[C@@H]2O[C@H](CN)[C@@H](O)[C@H]2O)[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)cc1 |r|
Structure:
