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Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50319252
Substrate
n/a
Meas. Tech.
ChEMBL_633873 (CHEMBL1120319)
IC50
7±n/a nM
Citation
 Ding, FX; Shen, HC; Wilsie, LC; Krsmanovic, ML; Taggart, AK; Ren, N; Cai, TQ; Wang, J; Tong, X; Holt, TG; Chen, Q; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A. Bioorg Med Chem Lett 20:3372-5 (2010) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Human
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50319252
Synonyms:
2-(3-(1-(5-hydroxypyridin-2-yl)-5-methyl-1H-pyrazol-4-yl)propanamido)cyclohex-1-enecarboxylicacid | CHEMBL1085148
Type:
Small organic molecule
Emp. Form.:
C19H22N4O4
Mol. Mass.:
370.4024
SMILES:
Cc1c(CCC(=O)NC2=C(CCCC2)C(O)=O)cnn1-c1ccc(O)cn1 |t:8|
Structure:
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