Reaction Details
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Glycogen phosphorylase, liver form
Ligand
BDBM50320331
Substrate
n/a
Meas. Tech.
ChEMBL_635773 (CHEMBL1120661)
IC50
17±n/a nM
Citation
Bennett, SN; Campbell, AD; Hancock, A; Johnstone, C; Kenny, PW; Pickup, A; Plowright, AT; Selmi, N; Simpson, I; Stocker, A; Whalley, DP; Whittamore, PR Discovery of a series of indan carboxylic acid glycogen phosphorylase inhibitors. Bioorg Med Chem Lett 20:3511-4 (2010) [PubMed] Article More Info.:
Target
Name:
Glycogen phosphorylase, liver form
Synonyms:
Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN
Type:
Homodimer
Mol. Mass.:
97153.98
Organism:
Human
Description:
Dimers associate into a tetramer to form the enzymatically active phosphorylase A.
Residue:
847
Sequence:
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
Inhibitor
Name:
BDBM50320331
Synonyms:
(S)-2-((1R,2R)-2-(2,3-DICHLORO-4H-THIENO[3,2-B]PYRROLE-5-CARBOXAMIDO)-2,3-DIHYDRO-1H-INDEN-1-YL)-4-METHOXYBUTANOIC ACID (DIASTEREOMERIC MIX) | (S)-2-((1R,2R)-2-(2,3-di chloro-4H-thieno[3,2-b]pyrrole-5-carboxamido)-2,3-dihydro-1H-inden-1-yl)-4-methoxybutanoic acid | (S)-2-((1R,2R)-2-(2,3-dichloro-4H-thieno[3,2-b]pyrrole-5-carboxamido)-2,3-dihydro-1H-inden-1-yl)-4-methoxybutanoic acid | CHEMBL1084328
Type:
Small organic molecule
Emp. Form.:
C21H20Cl2N2O4S
Mol. Mass.:
467.365
SMILES:
COCCC([C@H]1[C@@H](Cc2ccccc12)NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1)C(O)=O |r|
Structure:
