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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50320884
Substrate
n/a
Meas. Tech.
ChEMBL_636347 (CHEMBL1169070)
Ki
43000±n/a nM
Citation
 Barros, CD; Amato, AA; de Oliveira, TB; Iannini, KB; Silva, AL; Silva, TG; Leite, ES; Hernandes, MZ; Alves de Lima, Mdo C; Galdino, SL; Neves, Fde A; Pitta, Ida R Synthesis and anti-inflammatory activity of new arylidene-thiazolidine-2,4-diones as PPARgamma ligands. Bioorg Med Chem 18:3805-11 (2010) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50320884
Synonyms:
3-(3-Chloro-benzyl)-5-(4-methanesulfonyl-benzylidene)-thiazolidine-2,4-dione | CHEMBL1164770
Type:
Small organic molecule
Emp. Form.:
C18H14ClNO4S2
Mol. Mass.:
407.891
SMILES:
CS(=O)(=O)c1ccc(\C=C2/SC(=O)N(Cc3cccc(Cl)c3)C2=O)cc1
Structure:
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