Reaction Details
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Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50321253
Substrate
n/a
Meas. Tech.
ChEMBL_638608 (CHEMBL1167726)
IC50
595000±n/a nM
Citation
Lecerclé, D; Clouet, A; Al-Dabbagh, B; Crouvoisier, M; Bouhss, A; Gravier-Pelletier, C; Le Merrer, Y Bacterial transferase MraY inhibitors: synthesis and biological evaluation. Bioorg Med Chem 18:4560-9 (2010) [PubMed] Article More Info.:
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_BACSU | mraY
Type:
PROTEIN
Mol. Mass.:
35531.14
Organism:
Bacillus subtilis
Description:
ChEMBL_796247
Residue:
324
Sequence:
MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKSHQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIKVVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVLFMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFLVFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFKTTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL
Inhibitor
Name:
BDBM50321253
Synonyms:
2,5-Anhydro-3,4-dihydroxy-1-deoxy-1-(uracil-1'-yl)-6-[5''-(4'''-aminomethyl-1H,1''',2''',3'''-triazol-1'''-yl)-1'',5''-dideoxy-2'',3''-dihydroxy-beta-D-ribos-1''-yl]-D-glucitol | CHEMBL1164865
Type:
Small organic molecule
Emp. Form.:
C18H26N6O9
Mol. Mass.:
470.4338
SMILES:
NCc1cn(C[C@H]2O[C@@H](OC[C@H]3O[C@@H](Cn4ccc(=O)[nH]c4=O)[C@@H](O)[C@@H]3O)[C@H](O)[C@@H]2O)nn1 |r|
Structure:
