Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM50322857
Substrate
n/a
Meas. Tech.
ChEMBL_644658 (CHEMBL1211637)
Ki
3.3±n/a nM
Citation
Liu, Q; Qian, W; Li, A; Biswas, K; Chen, JJ; Fotsch, C; Han, N; Yuan, C; Arik, L; Biddlecome, G; Johnson, E; Kumar, G; Lester-Zeiner, D; Ng, GY; Hungate, RW; Askew, BC Aryl sulfonamides containing tetralin allylic amines as potent and selective bradykinin B1 receptor antagonists. Bioorg Med Chem Lett 20:4593-7 (2010) [PubMed] Article
More Info.:
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Human
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Inhibitor
Name:
BDBM50322857
Synonyms:
(R)-3-phenyl-N-((R)-6-(3-(piperidin-1-yl)prop-1-en-2-yl)-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(3-(trifluoromethyl)phenylsulfonamido)propanamide | CHEMBL1210743
Type:
Small organic molecule
Emp. Form.:
C34H38F3N3O3S
Mol. Mass.:
625.744
SMILES:
FC(F)(F)c1cccc(c1)S(=O)(=O)N[C@H](CC(=O)N[C@@H]1CCCc2cc(ccc12)C(=C)CN1CCCCC1)c1ccccc1 |r|