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Target
Histamine H3 receptor
Ligand
BDBM50325477
Substrate
n/a
Meas. Tech.
ChEMBL_652205 (CHEMBL1228478)
Ki
24±n/a nM
Citation
 Ting, PC; Lee, JF; Albanese, MM; Wu, J; Aslanian, R; Favreau, L; Nardo, C; Korfmacher, WA; West, RE; Williams, SM; Anthes, JC; Rivelli, MA; Corboz, MR; Hey, JA The synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists. Bioorg Med Chem Lett 20:5004-8 (2010) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50325477
Synonyms:
1-(1-((1-(pyridin-4-ylmethyl)piperidin-4-yl)methyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one | CHEMBL1222487
Type:
Small organic molecule
Emp. Form.:
C24H31N5O
Mol. Mass.:
405.5358
SMILES:
O=c1[nH]c2ccccc2n1C1CCN(CC2CCN(Cc3ccncc3)CC2)CC1
Structure:
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