Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM19130
Substrate
n/a
Meas. Tech.
ChEMBL_672871 (CHEMBL1267846)
IC50
3±n/a nM
Citation
Hutt, DM; Herman, D; Rodrigues, AP; Noel, S; Pilewski, JM; Matteson, J; Hoch, B; Kellner, W; Kelly, JW; Schmidt, A; Thomas, PJ; Matsumura, Y; Skach, WR; Gentzsch, M; Riordan, JR; Sorscher, EJ; Okiyoneda, T; Yates, JR; Lukacs, GL; Frizzell, RA; Manning, G; Gottesfeld, JM; Balch, WE Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol 6:25-33 (2009) [PubMed] Article
More Info.:
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Human
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
Inhibitor
Name:
BDBM19130
Synonyms:
(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide | CHEMBL99 | TSA | Trichostatin A (TSA)
Type:
Small organic molecule
Emp. Form.:
C17H22N2O3
Mol. Mass.:
302.3682
SMILES:
CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C |w:8.7,2.1|