Reaction Details Report a problem with these data
Target
NADPH oxidase 4
Ligand
BDBM50330721
Substrate
n/a
Meas. Tech.
ChEMBL_685143 (CHEMBL1286959)
Ki
259±n/a nM
Citation
Laleu, B; Gaggini, F; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem 53:7715-30 (2010) [PubMed] Article
More Info.:
Target
Name:
NADPH oxidase 4
Synonyms:
KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase
Type:
PROTEIN
Mol. Mass.:
66954.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792879
Residue:
578
Sequence:
MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
Inhibitor
Name:
BDBM50330721
Synonyms:
4-((2-(2-chlorophenyl)-4-methyl-3,6-dioxo-2,3-dihydro-1H-pyrazolo[4,3-c]pyridin-5(6H)-yl)methyl)benzenesulfonamide | CHEMBL1276945
Type:
Small organic molecule
Emp. Form.:
C20H17ClN4O4S
Mol. Mass.:
444.891
SMILES:
Cc1n(Cc2ccc(cc2)S(N)(=O)=O)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12