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Target
Triosephosphate isomerase, glycosomal
Ligand
BDBM50332793
Substrate
n/a
Meas. Tech.
ChEMBL_696637 (CHEMBL1641188)
IC50
13000±n/a nM
Citation
Alvarez, G; Aguirre-López, B; Varela, J; Cabrera, M; Merlino, A; López, GV; Lavaggi, ML; Porcal, W; Di Maio, R; González, M; Cerecetto, H; Cabrera, N; Pérez-Montfort, R; de Gómez-Puyou, MT; Gómez-Puyou, A Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity. Eur J Med Chem 45:5767-72 (2010) [PubMed] Article
More Info.:
Target
Name:
Triosephosphate isomerase, glycosomal
Synonyms:
TIM | TPIS_TRYCR | Triose-phosphate isomerase
Type:
PROTEIN
Mol. Mass.:
27334.70
Organism:
Trypanosoma cruzi
Description:
ChEMBL_596695
Residue:
251
Sequence:
MASKPQPIAAANWKCNGSESLLVPLIETLNAATFDHDVQCVVAPTFLHIPMTKARLTNPKFQIAAQNAITRSGAFTGEVSLQILKDYGISWVVLGHSERRLYYGETNEIVAEKVAQACAAGFHVIVCVGETNEEREAGRTAAVVLTQLAAVAQKLSKEAWSRVVIAYEPVWAIGTGKVATPQQAQEVHELLRRWVRSKLGTDIAAQLRILYGGSVTAKNARTLYQMRDINGFLVGGASLKPEFVEIIEATK
Inhibitor
Name:
BDBM50332793
Synonyms:
2,6-Dibenzyl-4-(5-nitro-furan-2-ylm ethylene)-1,1-dioxo-1lambda*6*-[1,2 ,6]thiadiazinane-3,5-dione | CHEMBL1630897
Type:
Small organic molecule
Emp. Form.:
C22H17N3O7S
Mol. Mass.:
467.451
SMILES:
[#8-]-[#7+](=O)-c1ccc(\[#6]=[#6]-2\[#6](=O)-[#7](-[#6]-c3ccccc3)S(=O)(=O)[#7](-[#6]-c3ccccc3)-[#6]-2=O)o1