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Target
B-cell receptor CD22
Ligand
BDBM50338744
Substrate
n/a
Meas. Tech.
ChEMBL_727026 (CHEMBL1686886)
IC50
70±n/a nM
Citation
Abdu-Allah, HH; Watanabe, K; Completo, GC; Sadagopan, M; Hayashizaki, K; Takaku, C; Tamanaka, T; Takematsu, H; Kozutsumi, Y; Paulson, JC; Tsubata, T; Ando, H; Ishida, H; Kiso, M CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold. Bioorg Med Chem 19:1966-71 (2011) [PubMed] Article
More Info.:
Target
Name:
B-cell receptor CD22
Synonyms:
CD22 | CD22_HUMAN | SIGLEC2
Type:
PROTEIN
Mol. Mass.:
95348.60
Organism:
Human
Description:
ChEMBL_727026
Residue:
847
Sequence:
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH
Inhibitor
Name:
BDBM50338744
Synonyms:
(2R,4S,5R,6R)-2-(biphenyl-4-ylmethoxy)-6-((1R,2R)-1,2-dihydroxy-3-(2-(4'-hydroxybiphenyl-4-yl)acetamido)propyl)-4-hydroxy-5-(2-hydroxyacetamido)tetrahydro-2H-pyran-2-carboxylic acid | CHEMBL1684361
Type:
Small organic molecule
Emp. Form.:
C38H40N2O11
Mol. Mass.:
700.731
SMILES:
OCC(=O)N[C@@H]1[C@@H](O)C[C@@](OCc2ccc(cc2)-c2ccccc2)(O[C@H]1[C@H](O)[C@H](O)CNC(=O)Cc1ccc(cc1)-c1ccc(O)cc1)C(O)=O |r|