Reaction Details Report a problem with these data
Target
RAC-alpha serine/threonine-protein kinase
Ligand
BDBM50339825
Substrate
n/a
Meas. Tech.
ChEMBL_740602 (CHEMBL1764865)
IC50
26±n/a nM
Citation
Kallan, NC; Spencer, KL; Blake, JF; Xu, R; Heizer, J; Bencsik, JR; Mitchell, IS; Gloor, SL; Martinson, M; Risom, T; Gross, SD; Morales, TH; Wu, WI; Vigers, GP; Brandhuber, BJ; Skelton, NJ Discovery and SAR of spirochromane Akt inhibitors. Bioorg Med Chem Lett 21:2410-4 (2011) [PubMed] Article
More Info.:
Target
Name:
RAC-alpha serine/threonine-protein kinase
Synonyms:
AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)
Type:
Enzyme
Mol. Mass.:
55681.25
Organism:
Homo sapiens (Human)
Description:
P31749
Residue:
480
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Inhibitor
Name:
BDBM50339825
Synonyms:
1'-((S)-3-(N-(2-ethoxyethyl)-2,6-dimethylphenylsulfonamido)-2-hydroxypropyl)spiro[chroman-2,3'-piperidine]-6-carboxamide | CHEMBL1761088
Type:
Small organic molecule
Emp. Form.:
C29H41N3O6S
Mol. Mass.:
559.717
SMILES:
CCOCCN(C[C@@H](O)CN1CCCC2(CCc3cc(ccc3O2)C(N)=O)C1)S(=O)(=O)c1c(C)cccc1C |r|