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Target
Sodium/myo-inositol cotransporter 2
Ligand
BDBM50340013
Substrate
n/a
Meas. Tech.
ChEMBL_740127 (CHEMBL1763187)
IC50
9200±n/a nM
Citation
 Li, AR; Zhang, J; Greenberg, J; Lee, T; Liu, J Discovery of non-glucoside SGLT2 inhibitors. Bioorg Med Chem Lett 21:2472-5 (2011) [PubMed]  Article 
Target
Name:
Sodium/myo-inositol cotransporter 2
Synonyms:
KST1 | Na(+)/myo-inositol cotransporter 2 | SC5AB_HUMAN | SLC5A11 | SLGTX | SMIT2 | Sodium-dependent glucose cotransporter | Sodium/glucose cotransporter KST1 | Solute carrier family 5 member 11
Type:
PROTEIN
Mol. Mass.:
74036.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_740127
Residue:
675
Sequence:
MESGTSSPQPPQLDPLDAFPQKGLEPGDIAVLVLYFLFVLAVGLWSTVKTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAATGISVSAYELNGLFSVLMLAWIFLPIYIAGQVTTMPEYLRKRFGGIRIPIILAVLYLFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIMLIGALTLMGYSFAAVGGMEGLKEKYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMVFPGMVSRILFPDQVACADPEICQKICSNPSGCSDIAYPKLVLELLPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWNHLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGLLLGLVRLVLDFIYVQPRCDQPDERPVLVKSIHYLYFSMILSTVTLITVSTVSWFTEPPSKEMVSHLTWFTRHDPVVQKEQAPPAAPLSLTLSQNGMPEASSSSSVQFEMVQENTSKTHSCDMTPKQSKVVKAILWLCGIQEKGKEELPARAEAIIVSLEENPLVKTLLDVNLIFCVSCAIFIWGYFA
  
Inhibitor
Name:
BDBM50340013
Synonyms:
6,8-dichloro-4-((5-(4-chlorophenethyl)-4-(3,3,3-trifluoropropyl)-4H-1,2,4-triazol-3-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one | CHEMBL1762505
Type:
Small organic molecule
Emp. Form.:
C22H18Cl3F3N4O2
Mol. Mass.:
533.758
SMILES:
FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN1C(=O)COc2c(Cl)cc(Cl)cc12
Structure:
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