Reaction Details
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6-phosphogluconate dehydrogenase, decarboxylating
Ligand
BDBM50342610
Substrate
n/a
Meas. Tech.
ChEMBL_744988 (CHEMBL1772003)
IC50
5800±n/a nM
Citation
Yep, A; Sorenson, RJ; Wilson, MR; Showalter, HD; Larsen, SD; Keller, PR; Woodard, RW Enediol mimics as inhibitors of the D-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis. Bioorg Med Chem Lett 21:2679-82 (2011) [PubMed] Article More Info.:
Target
Name:
6-phosphogluconate dehydrogenase, decarboxylating
Synonyms:
6-phosphogluconate dehydrogenase, decarboxylating, putative
Type:
PROTEIN
Mol. Mass.:
52169.87
Organism:
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Description:
ChEMBL_744988
Residue:
479
Sequence:
MSMDVGVVGLGVMGANLALNIAEKGFKVAVFNRTYSKSEEFMKANASAPFAGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVFEKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDGRPCVTMNGSGGAGSCVKMYHNSGEYAILQIWGEVFDILRAMGLNNDEVAAVLEDWKSKNFLKSYMLDISIAAARAKDKDGSYLTEHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSPGYTLKNKSPSGPEIKQLYDSVCIAIISCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMCAFQTEIRAGLQNYRDMVALITSKLEVSIPVLSASLNYVTAMFTPTLKYGQLVSLQRDVFGRHGYERVDKDGRESFQWPELQ
Inhibitor
Name:
BDBM50342610
Synonyms:
(2R,3R,4S)-2,3,4-trihydroxy-5-(hydroxyamino)-5-oxopentyl phosphate | 5-PHOSPHO-D-ARABINOHYDROXAMIC ACID | CHEMBL1235136
Type:
Small organic molecule
Emp. Form.:
C5H12NO9P
Mol. Mass.:
261.1238
SMILES:
ONC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O |r|
Structure:
