Reaction Details
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Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50342779
Substrate
n/a
Meas. Tech.
ChEMBL_744419 (CHEMBL1772373)
IC50
190000±n/a nM
Citation
Mravljak, J; Monasson, O; Al-Dabbagh, B; Crouvoisier, M; Bouhss, A; Gravier-Pelletier, C; Le Merrer, Y Synthesis and biological evaluation of a diazepanone-based library of liposidomycins analogs as MraY inhibitors. Eur J Med Chem 46:1582-92 (2011) [PubMed] Article More Info.:
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_STAAU | mraY
Type:
PROTEIN
Mol. Mass.:
35238.55
Organism:
Staphylococcus aureus (strain MRSA252)
Description:
ChEMBL_827497
Residue:
321
Sequence:
MIFVYALLALVITFVLVPVLIPTLKRMKFGQSIREEGPQSHMKKTGTPTMGGLTFLLSIVITSLVAIIFVDQANPIILLLFVTIGFGLIGFIDDYIIVVKKNNQGLTSKQKFLAQIGIAIIFFVLSNVFHLVNFSTSIHIPFTNVAIPLSFAYVIFIVFWQVGFSNAVNLTDGLDGLATGLSIIGFTMYAIMSFVLGETAIGIFCIIMLFALLGFLPYNINPAKVFMGDTGSLALGGIFATISIMLNQELSLIFIGLVFVIETLSVMLQVASFKLTGKRIFKMSPIHHHFELIGWSEWKVVTVFWAVGLISGLIGLWIGVH
Inhibitor
Name:
BDBM50342779
Synonyms:
(3S,6S,7R)-7-tert-Butyldiphenylsilyloxymethyl-4-N-(5''-(uracil-1'-yl)pentyl)-6-palmitoyloxy-3-(5-azido-5-deoxy-2,3-Oisopentylidene-beta-D-ribos-1-yl-methyl)-1,4-diazepan-2-one | CHEMBL1770414
Type:
Small organic molecule
Emp. Form.:
C58H89N7O10Si
Mol. Mass.:
1072.4537
SMILES:
CCCCCCCCCCCCCCCC(=O)O[C@H]1CN(CCCCCn2ccc(=O)[nH]c2=O)[C@@H](CO[C@@H]2O[C@H](CN=[N+]=[N-])[C@H]3OC(CC)(CC)O[C@@H]23)C(=O)N[C@@H]1CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C |r|
Structure:
