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Target
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50342784
Substrate
n/a
Meas. Tech.
ChEMBL_744419 (CHEMBL1772373)
IC50
310000±n/a nM
Citation
 Mravljak, J; Monasson, O; Al-Dabbagh, B; Crouvoisier, M; Bouhss, A; Gravier-Pelletier, C; Le Merrer, Y Synthesis and biological evaluation of a diazepanone-based library of liposidomycins analogs as MraY inhibitors. Eur J Med Chem 46:1582-92 (2011) [PubMed]  Article 
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_STAAU | mraY
Type:
PROTEIN
Mol. Mass.:
35238.55
Organism:
Staphylococcus aureus (strain MRSA252)
Description:
ChEMBL_827497
Residue:
321
Sequence:
MIFVYALLALVITFVLVPVLIPTLKRMKFGQSIREEGPQSHMKKTGTPTMGGLTFLLSIVITSLVAIIFVDQANPIILLLFVTIGFGLIGFIDDYIIVVKKNNQGLTSKQKFLAQIGIAIIFFVLSNVFHLVNFSTSIHIPFTNVAIPLSFAYVIFIVFWQVGFSNAVNLTDGLDGLATGLSIIGFTMYAIMSFVLGETAIGIFCIIMLFALLGFLPYNINPAKVFMGDTGSLALGGIFATISIMLNQELSLIFIGLVFVIETLSVMLQVASFKLTGKRIFKMSPIHHHFELIGWSEWKVVTVFWAVGLISGLIGLWIGVH
  
Inhibitor
Name:
BDBM50342784
Synonyms:
(3S,6S,7R)-3,7-Di-(5-amino-5-deoxy-2,3-O-isopentylidene-beta-D-ribos-1-yl-methyl)-4-N-(5''-(uracil-1'-yl)pentyl)-6-palmitoyloxy-1,4-diazepan-2-one | CHEMBL1770419
Type:
Small organic molecule
Emp. Form.:
C52H90N6O13
Mol. Mass.:
1007.3034
SMILES:
CCCCCCCCCCCCCCCC(=O)O[C@H]1CN(CCCCCn2ccc(=O)[nH]c2=O)[C@@H](CO[C@@H]2O[C@H](CN)[C@H]3OC(CC)(CC)O[C@@H]23)C(=O)N[C@@H]1CO[C@@H]1O[C@H](CN)[C@H]2OC(CC)(CC)O[C@@H]12 |r|
Structure:
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