Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50348152
Substrate
n/a
Meas. Tech.
ChEMBL_757185 (CHEMBL1803409)
Ki
2.36±n/a nM
Citation
 Baraldi, PG; Preti, D; Zaid, AN; Saponaro, G; Tabrizi, MA; Baraldi, S; Romagnoli, R; Moorman, AR; Varani, K; Cosconati, S; Di Maro, S; Marinelli, L; Novellino, E; Borea, PA New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists. J Med Chem 54:5205-20 (2011) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50348152
Synonyms:
CHEMBL1800781
Type:
Small organic molecule
Emp. Form.:
C16H19N7O2
Mol. Mass.:
341.3678
SMILES:
COc1cc(-c2nc3c4NC(C)Cn4c(=O)n(CC=C)c3n2)n(C)n1
Structure:
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