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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50352568
Substrate
n/a
Meas. Tech.
ChEMBL_767363 (CHEMBL1825475)
IC50
5±n/a nM
Citation
 Eastwood, P; González, J; Gómez, E; Caturla, F; Balagué, C; Orellana, A; Domínguez, M Indolin-2-one p38a inhibitors II: Lead optimisation. Bioorg Med Chem Lett 21:5270-3 (2011) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Human
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50352568
Synonyms:
CHEMBL1825151
Type:
Small organic molecule
Emp. Form.:
C24H26N2O3
Mol. Mass.:
390.4748
SMILES:
Cc1ccc(cc1-c1ccc2c(NC(=O)[C@@]22CC[C@H](O)CC2)c1)C(=O)NC1CC1 |r,wD:15.15,18.20,(-4.28,-16.05,;-2.94,-16.81,;-1.62,-16.03,;-.27,-16.8,;-.27,-18.34,;-1.6,-19.11,;-2.94,-18.35,;-4.26,-19.12,;-4.26,-20.67,;-5.59,-21.44,;-6.93,-20.67,;-6.92,-19.13,;-8.39,-18.65,;-9.29,-19.9,;-10.83,-19.89,;-8.39,-21.14,;-7.3,-22.23,;-7.71,-23.72,;-9.2,-24.12,;-9.6,-25.6,;-10.29,-23.02,;-9.89,-21.54,;-5.6,-18.35,;1.07,-19.11,;1.07,-20.65,;2.4,-18.33,;3.73,-19.1,;4.51,-20.43,;5.28,-19.09,)|
Structure:
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