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Target
Endothelin-1 receptor
Ligand
BDBM50284768
Substrate
n/a
Meas. Tech.
ChEBML_65805
IC50
2000±n/a nM
Citation
 Fukami, T; Yamakawa, T; Kojima, H; Amano, Y; Ihara, M; Yano, M; Ishikawa, K Synthesis of 2-substituted d-tryptophan-containing peptide derivatives with endothelin receptor antagonist activity Bioorg Med Chem Lett 5:1483-1488 (1995)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_PIG | Endothelin receptor ET-A
Type:
PROTEIN
Mol. Mass.:
48707.29
Organism:
Sus scrofa
Description:
ChEMBL_65803
Residue:
427
Sequence:
METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN
  
Inhibitor
Name:
BDBM50284768
Synonyms:
(S)-2-((R)-3-(2-Cyano-1H-indol-3-yl)-2-{2-[((2R,6S)-2,6-dimethyl-piperidine-1-carbonyl)-amino]-3-methyl-butyrylamino}-propionylamino)-hexanoic acid | CHEMBL431124
Type:
Small organic molecule
Emp. Form.:
C31H44N6O5
Mol. Mass.:
580.7183
SMILES:
CCCC[C@H](NC(=O)[C@@H](Cc1c([nH]c2ccccc12)C#N)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(O)=O
Structure:
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