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Target
Endothelin-1 receptor
Ligand
BDBM50284773
Substrate
n/a
Meas. Tech.
ChEBML_65805
IC50
180±n/a nM
Citation
 Fukami, T; Yamakawa, T; Kojima, H; Amano, Y; Ihara, M; Yano, M; Ishikawa, K Synthesis of 2-substituted d-tryptophan-containing peptide derivatives with endothelin receptor antagonist activity Bioorg Med Chem Lett 5:1483-1488 (1995)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_PIG | Endothelin receptor ET-A
Type:
PROTEIN
Mol. Mass.:
48707.29
Organism:
Sus scrofa
Description:
ChEMBL_65803
Residue:
427
Sequence:
METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN
  
Inhibitor
Name:
BDBM50284773
Synonyms:
(S)-2-[(R)-2-{2-[((2R,6S)-2,6-Dimethyl-piperidine-1-carbonyl)-amino]-4-methyl-pentanoylamino}-3-(2-ethyl-1H-indol-3-yl)-propionylamino]-hexanoic acid | CHEMBL287888
Type:
Small organic molecule
Emp. Form.:
C33H51N5O5
Mol. Mass.:
597.7885
SMILES:
CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(O)=O
Structure:
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