Reaction Details Report a problem with these data
Target
Vacuolar proton pump subunit B
Ligand
BDBM50064182
Substrate
n/a
Meas. Tech.
ChEMBL_148285 (CHEMBL750200)
IC50
49±n/a nM
Citation
Edvinsson, KM; Herslöf, M; Holm, P; Kann, N; Keeling, DJ; Mattsson, JP; Nordén, B; Shcherbukhin, V Solid phase synthesis of diamides as potential bone resorption inhibitors. Bioorg Med Chem Lett 10:503-7 (2000) [PubMed] Article
More Info.:
Target
Name:
Vacuolar proton pump subunit B
Synonyms:
Adenosinetriphosphatase | Uncharacterized protein | Vacuolar H-ATPase B subunit osteoclast isozyme
Type:
PROTEIN
Mol. Mass.:
55043.78
Organism:
Gallus gallus
Description:
ChEMBL_148284
Residue:
496
Sequence:
RRMVNGAGPGGAREQAAALTRDFLSQPRLTYKTVSGVNGPLVILDQVKFPRYAEIVHLTLPDGTRRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPAVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVMDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFEKNFIAQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQTTLAEFYPRDSTAKH
Inhibitor
Name:
BDBM50064182
Synonyms:
(2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-penta-2,4-dienoic acid (2,2,6,6-tetramethyl-piperidin-4-yl)-amide | CHEMBL449696
Type:
Small organic molecule
Emp. Form.:
C23H29Cl2N3O2
Mol. Mass.:
450.401
SMILES:
CO\C(=C/C=C/c1cc2cc(Cl)c(Cl)cc2[nH]1)C(=O)NC1CC(C)(C)NC(C)(C)C1