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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50096656
Substrate
n/a
Meas. Tech.
ChEBML_140633
IC50
129±n/a nM
Citation
 Corbett, JW; Kresge, KJ; Pan, S; Cordova, BC; Klabe, RM; Rodgers, JD; Erickson-Viitanen, SK Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase. Bioorg Med Chem Lett 11:309-12 (2001) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50096656
Synonyms:
3-(1-Butoxy-3-cyclopropyl-1-trifluoromethyl-prop-2-ynyl)-5-ethyl-6-methyl-1H-pyridin-2-one | CHEMBL107693
Type:
Small organic molecule
Emp. Form.:
C19H24F3NO2
Mol. Mass.:
355.3946
SMILES:
CCCCOC(C#CC1CC1)(c1cc(CC)c(C)[nH]c1=O)C(F)(F)F
Structure:
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