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Target
Renin
Ligand
BDBM50014084
Substrate
n/a
Meas. Tech.
ChEMBL_192725 (CHEMBL801752)
pH
7.4±n/a
IC50
0.330000±n/a nM
Comments
extracted
Citation
 Rosenberg, SH; Woods, KW; Sham, HL; Kleinert, HD; Martin, DL; Stein, H; Cohen, J; Egan, DA; Bopp, B; Merits, I Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action. J Med Chem 33:1962-9 (1990) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50014084
Synonyms:
(R)-2-Benzyl-N*1*-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N*4*-[2-(2-methoxy-ethoxymethoxy)-ethyl]-N*4*-methyl-succinamide | CHEMBL58263
Type:
Small organic molecule
Emp. Form.:
C38H58N6O9
Mol. Mass.:
742.9019
SMILES:
CCN1C[C@H](OC1=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](CC(=O)N(C)CCOCOCCOC)Cc1ccccc1
Structure:
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