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Target
Purine nucleoside phosphorylase
Ligand
BDBM50005801
Substrate
n/a
Meas. Tech.
ChEBML_162178
IC50
13400±n/a nM
Citation
 Woo, PW; Kostlan, CR; Sircar, JC; Dong, MK; Gilbertsen, RB Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues. J Med Chem 35:1451-7 (1992) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50005801
Synonyms:
3-Benzyl-2-hydroxy-1,9-dihydro-purin-6-one | CHEMBL33826
Type:
Small organic molecule
Emp. Form.:
C12H10N4O2
Mol. Mass.:
242.2334
SMILES:
O=c1[nH]c(=O)c2[nH]cnc2n1Cc1ccccc1
Structure:
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