Reaction Details
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Target
Translocator protein
Ligand
BDBM50052314
Substrate
n/a
Meas. Tech.
ChEMBL_37074 (CHEMBL650011)
Ki
569±n/a nM
Citation
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More Info.:
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
Inhibitor
Name:
BDBM50052314
Synonyms:
Acetic acid (4R,5R)-9-chloro-1-dimethylaminomethyl-5-phenyl-4,5-dihydro-6-thia-10b-aza-benzo[e]azulen-4-yl ester | CHEMBL99871
Type:
Small organic molecule
Emp. Form.:
C23H23ClN2O2S
Mol. Mass.:
426.959
SMILES:
CN(C)Cc1ccc2[C@@H](OC(C)=O)[C@H](Sc3ccc(Cl)cc3-n12)c1ccccc1