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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50064193
Substrate
n/a
Meas. Tech.
ChEMBL_200979 (CHEMBL801232)
Ki
9.6±n/a nM
Citation
 Ronsisvalle, G; Marrazzo, A; Prezzavento, O; Pasquinucci, L; Vittorio, F; Pittalà, V; Pappalardo, MS; Cacciaguerra, S; Spampinato, S (+)-cis-N-ethyleneamino-N-normetazocine derivatives. Novel and selective sigma ligands with antagonist properties. J Med Chem 41:1574-80 (1998) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50064193
Synonyms:
(2S,6R,11S)-6,11-Dimethyl-3-(2-piperidin-1-yl-ethyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol | CHEMBL41313
Type:
Small organic molecule
Emp. Form.:
C21H32N2O
Mol. Mass.:
328.4916
SMILES:
C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CCN1CCCCC1 |TLB:16:15:1:10.4.3|
Structure:
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