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Target
Neuromedin-K receptor
Ligand
BDBM50074808
Substrate
n/a
Meas. Tech.
ChEMBL_209565 (CHEMBL811267)
Ki
454±n/a nM
Citation
 Giardina, GA; Raveglia, LF; Grugni, M; Sarau, HM; Farina, C; Medhurst, AD; Graziani, D; Schmidt, DB; Rigolio, R; Luttmann, M; Cavagnera, S; Foley, JJ; Vecchietti, V; Hay, DW Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412). J Med Chem 42:1053-65 (1999) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3)
Type:
Enzyme
Mol. Mass.:
52221.96
Organism:
Homo sapiens (Human)
Description:
P29371
Residue:
465
Sequence:
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
  
Inhibitor
Name:
BDBM50074808
Synonyms:
2-Phenyl-quinoline-4-carboxylic acid (2,2,2-trifluoro-1-phenyl-ethyl)-amide | CHEMBL275316
Type:
Small organic molecule
Emp. Form.:
C24H17F3N2O
Mol. Mass.:
406.3998
SMILES:
FC(F)(F)C(NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccc1
Structure:
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