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Target
Kappa-type opioid receptor
Ligand
BDBM50083924
Substrate
n/a
Meas. Tech.
ChEMBL_146517 (CHEMBL754626)
Ki
720±n/a nM
Citation
 Neumeyer, JL; Bidlack, JM; Zong, R; Bakthavachalam, V; Gao, P; Cohen, DJ; Negus, SS; Mello, NK Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence. J Med Chem 43:114-22 (2000) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Guinea pig
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50083924
Synonyms:
8-Hydroxy-6,11-dimethyl-3-(tetrahydro-furan-2-ylmethyl)-3,4,5,6-tetrahydro-2H-2,6-methano-benzo[d]azocin-1-one | CHEMBL280958
Type:
Small organic molecule
Emp. Form.:
C19H25NO3
Mol. Mass.:
315.4067
SMILES:
C[C@H]1C2N(CC3CCCO3)CC[C@]1(C)c1cc(O)ccc1C2=O |TLB:4:3:21.14.20:1,15:14:1:3.11.10,THB:22:21:1:3.11.10|
Structure:
Search PDB for entries with ligand similarity: