Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Ligand
BDBM50173540
Substrate
n/a
Meas. Tech.
ChEMBL_320965 (CHEMBL885372)
Ki
1200±n/a nM
Citation
Nguyen, C; Kasinathan, G; Leal-Cortijo, I; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Pérez, LM; Johansson, NG; González-Pacanowska, D; Gilbert, IH Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J Med Chem 48:5942-54 (2005) [PubMed] Article
More Info.:
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Synonyms:
dUTP pyrophosphatase
Type:
Protein
Mol. Mass.:
19574.43
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
Q8II92
Residue:
173
Sequence:
MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKSNYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAALDNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
Inhibitor
Name:
BDBM50173540
Synonyms:
1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione | CHEMBL371690 | dUTPase inhibitor, 5
Type:
Small organic molecule
Emp. Form.:
C25H28N2O4Si
Mol. Mass.:
448.5863
SMILES:
CC(C)(C)[Si](OCC1OC(C=C1)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1 |c:10|