Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Ligand
BDBM50173538
Substrate
n/a
Meas. Tech.
ChEMBL_320965 (CHEMBL885372)
Ki
189000±n/a nM
Citation
 Nguyen, C; Kasinathan, G; Leal-Cortijo, I; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Pérez, LM; Johansson, NG; González-Pacanowska, D; Gilbert, IH Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J Med Chem 48:5942-54 (2005) [PubMed]  Article 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Synonyms:
dUTP pyrophosphatase
Type:
Protein
Mol. Mass.:
19574.43
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
Q8II92
Residue:
173
Sequence:
MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKSNYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAALDNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
  
Inhibitor
Name:
BDBM50173538
Synonyms:
CHEMBL372635 | Pentanoic acid [5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-amide
Type:
Small organic molecule
Emp. Form.:
C14H21N3O5
Mol. Mass.:
311.3336
SMILES:
CCCCC(=O)NCC1OC(CC1O)n1ccc(=O)[nH]c1=O
Structure:
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