Reaction Details
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Guanine nucleotide-binding protein G(o) subunit alpha
Ligand
BDBM50174648
Substrate
n/a
Meas. Tech.
ChEMBL_321106 (CHEMBL882872)
EC50
8200±n/a nM
Citation
Manetti, D; Di Cesare Mannelli, L; Dei, S; Galeotti, N; Ghelardini, C; Romanelli, MN; Scapecchi, S; Teodori, E; Pacini, A; Bartolini, A; Gualtieri, F Design, synthesis, and preliminary pharmacological evaluation of a set of small molecules that directly activate gi proteins. J Med Chem 48:6491-503 (2005) [PubMed] Article More Info.:
Target
Name:
Guanine nucleotide-binding protein G(o) subunit alpha
Synonyms:
GNAO1 | GNAO_HUMAN | Guanine nucleotide-binding protein G(o), alpha subunit 1 | guanine nucleotide-binding protein G(o) subunit alpha isoform a
Type:
PROTEIN
Mol. Mass.:
40043.59
Organism:
Human
Description:
ChEMBL_321106
Residue:
354
Sequence:
MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
Inhibitor
Name:
BDBM50174648
Synonyms:
CHEMBL536499 | Piperidine-4-carboxylic acid pentadecylamide; hydrochloride
Type:
Small organic molecule
Emp. Form.:
C21H42N2O
Mol. Mass.:
338.571
SMILES:
CCCCCCCCCCCCCCCNC(=O)C1CCNCC1
Structure:
